| 2015-05-05 | Joint reporting: Thomas, McNerney & Partners II L.P.; TMP Associates II LP; TMP Nominee II, LLC; Thomas, McNerney & Partners II, LLC | U | — |
| 2015-05-05 | Joint reporting: DEERFIELD MANAGEMENT CO; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, LP; Flynn James E; Deerfield Special Situations Fund, L.P.; Deerfield Private Design International II, L.P.; Deerfield Private Design Fund II, L.P.; Deerfield International Master Fund, L.P. | U | — |
| 2015-05-05 | Joint reporting: DEERFIELD MANAGEMENT CO; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, LP; Flynn James E; Deerfield Special Situations Fund, L.P.; Deerfield Private Design International II, L.P.; Deerfield Private Design Fund II, L.P.; Deerfield International Master Fund, L.P. | U | — |
| 2015-05-05 | Joint reporting: DEERFIELD MANAGEMENT CO; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, LP; Flynn James E; Deerfield Special Situations Fund, L.P.; Deerfield Private Design International II, L.P.; Deerfield Private Design Fund II, L.P.; Deerfield International Master Fund, L.P. | U | — |
| 2015-05-05 | Joint reporting: DEERFIELD MANAGEMENT CO; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, LP; Flynn James E; Deerfield Special Situations Fund, L.P.; Deerfield Private Design International II, L.P.; Deerfield Private Design Fund II, L.P.; Deerfield International Master Fund, L.P. | U | — |
| 2015-05-05 | Joint reporting: DEERFIELD MANAGEMENT CO; Deerfield Mgmt L.P.; DEERFIELD PARTNERS, LP; Flynn James E; Deerfield Special Situations Fund, L.P.; Deerfield Private Design International II, L.P.; Deerfield Private Design Fund II, L.P.; Deerfield International Master Fund, L.P. | U | — |
| 2015-05-05 | Zisson Alex | U | — |
| 2015-05-05 | Shah Pratik(President and CEO) | D | — |
| 2015-05-05 | Shah Pratik(President and CEO) | D | — |
| 2015-05-05 | Shah Pratik(President and CEO) | D | — |
| 2015-05-05 | Shah Pratik(President and CEO) | U | — |
| 2015-05-05 | Schmid John P.(Chief Financial Officer) | D | — |
| 2015-05-05 | Schmid John P.(Chief Financial Officer) | D | — |
| 2015-05-05 | Schmid John P.(Chief Financial Officer) | D | — |
| 2015-05-05 | Schmid John P.(Chief Financial Officer) | U | — |
| 2015-05-05 | Stamler David A(Chief Medical Officer) | D | — |
| 2015-05-05 | Stamler David A(Chief Medical Officer) | D | — |
| 2015-05-05 | Stamler David A(Chief Medical Officer) | D | — |
| 2015-05-05 | Stamler David A(Chief Medical Officer) | D | — |
| 2015-05-05 | Stamler David A(Chief Medical Officer) | D | — |